Fort Myers is a good base for a short visit. It's not directly on the beach, but its central location makes day trips easy.
Day 1
On the morning of your first day, visit Edison & Ford Winter Estates, in downtown Fort Myers, and then take McGregor Boulevard and Summerlin Road to Sanibel Island. There, stop by the Bailey-Matthews Shell Museum and the J. N. "Ding" Darling National Wildlife Refuge before heading to Bowman's Beach for shelling, swimming, and its famous sunset.
Day 2
The next day drive down Interstate 75 to Naples. Check out the subtropical plants and exotic animals at Naples Zoo. If you have a heart for art, stop by the Naples Museum of Art before hitting Old Naples for some shopping and relaxing on the nearby beach.
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